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Related post: LPD, NIAID LSM. DCRT LPD, NIAID LSM, DCRT LPD, NIAID COOPERATING UNITS (It any) Laboratoire de Pathologie Cellulaire du Foie, Institut Pasteur, Lyon (Jean-Alexis Grimaud). Division of Infectious Diseases, George Washington University (CarmelitaTuazon, Ann Labriola). LAeraRANCH Laboratroy of Parasitic Diseases SECTION Host-Parasite Relations Section iNsrrnjTB ano location NIAID, NIH, Bethesda. Maryland 20892 total MAN-YEARS: 1.0 PROfESSKSNAL: 0.50 0.50 CHECK appropriate B0XBuy Sildalis areas of fibrosis become smaller but denser. Mice vaccinated with paramyosin and BCG showed no significant difference in granuloma size or hepatic fibrosis compared to nonvaccinated mice. PHS S040(R«« 1f84) S^O •! 4-«ll 14-33 OtPABTMENT Of HEALTH ANO HUMAN SERVICES • PUBLIC HEALTH SEBVICE NOTICE OF INTRAMURAL RESEARCH PROJECT Z01 A! 00350-06 LPD CctcDer 1. 1987 to September 30. 1988 3NA Analy SIS of Parasites "mjt m v »* o»r»9»r -n« oonjun PI: Others: T.E.Nash Medical Officer LPD, NIAlD A. Agganwal Visiting Fellow LPD, NIAID R. Adam Medical Staff Fellow LPD. NIAID T. McCutchan Senior Scientist LPD. NIAID T. Wellems Staff Fellow LPD. NIAID V. de la Cruz Staff Fellow LPD. NIAID None LAa^BAANCH Laboratory of Parasitic Diseases SEcncN Host-Parasite Relations Section iNSTTTV/Tf ANO LOCATION NIAID, NIH, Bethesda. Maryland 20892 'OTAC OAM-vEAPS P<»OfESS»ONAL. ! OTMEB: 2.2 1.7 i 0.5 CHECX A^»«»OP«iArE OOXJIS) Z (a) Human sutaiects C (b) Human tissues O (c) Neither _ (ai) Minors ~ (a2) Interviews SUWMAAV Of M}RK lUm taraara .yvwucstf rypft Oo nai »icni» cn« loaca ortKnaaa.) Giardia surface antigens undergo antigenic variation. To detennine the relatedness of one vanant to another. cDNA libraries of two related variants were successfully produced and screened with surface specific Mab or previously defined DNA probes. Analysis and sequencing are in progress. Pulse field gradient analysis of Giardia chromosomes continue. One minor band was related to one of the major chromosomes. Markers were derived product is recognized by all infected animals and humans. SEquencing of this gene revealed no relationship to other proteins. This antigen may be vaJuable for detecting Giardia specific antibody responses. Attempts to transform Giardia continue. Constructs were made using a Giardia heat shock promotor and the iacZ gene and used to transform Giardia . Giardia were transformed transiently. U-34 OEPAPTMENT OF HEALTH AND HUMAN SERVICES ■ PUBUC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT Z01 Al 00351-06 LPD PEBIOO COVEHED October 1 , 1 987 to September 30. 1988 TTTLE OP PROJECT ISO cnarmaan or nu. Titim mutt tit an on* iirm OMwaan mm oonars.) Parasite and Host Factors Controlling the Pathogenesis of Leishmaniasis Pnil^lPAL INVESTIGATOR (List airmr protnaionm ptneiml OaWw m* Prmopai Invmatigttor ) (Nam: no*. itDerttory. tna mnmn tmiitoon) Expert LPD. NIAID Section Head LPD, NIAID Chief LPD. NIAID Biologist LPD, NIAID Supvr. Microbiologist LPD. NIAID Guest Researcher LPD, NIAID Guest Researcher LPD. NIAID
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